Saturday, December 28, 2019

1.Non-Proliferative Breast Disease. Non-Proliferative Breast

1. Non-proliferative Breast Disease Non-proliferative breast disease, the most common lesion, is associated with small increased risk or no effect (relative risk 0.9-1.6) (e.g., fibroadenoma, cysts). 2. Proliferative Breast Disease without Atypia Women with proliferative breast disease without atypia had about 1.5 to 1.9 fold increased risk (e.g., adenosis, intraductal papilloma). 3. Atypical Hyperplasia Atypical hyperplasia produced about a 3 to 5 fold higher risk of breast cancer. Pathology of Breast Cancer Breast cancers can be classified by different schemes. Each of these aspects influences treatment response and prognosis. Description of a breast cancer would optimally include all of these classification aspects, as well as other†¦show more content†¦Patients with a high score benefit from radiotherapy after excision, whereas those of low grade, whose tumor is completely excised, need no further treatment. (Williams, et al., 2013) Surgical Treatment Options of DCIS a. Mastectomy for Patients with DCIS Mastectomy is by far the most effective treatment available for DCIS if the goal is simply to prevent local recurrence. Most mastectomy series reveal local recurrence rates of approximately 1% with mortality rates close to zero. Mastectomy is an aggressive form of treatment for patients with DCIS. It clearly provides a local recurrence benefit but only an indemonstrable and theoretical survival benefit. It is, therefore, often difficult to justify mastectomy, particularly for otherwise healthy women with screen-detected DCIS, during an era of increasing utilization of breast conservation for invasive breast carcinoma. Mastectomy is indicated in cases of true multicentricity (multi-quadrant disease) and when a unicentric DCIS lesion is too extensive to excise with clear margins and an acceptable cosmetic result. Genetic positivity to one or more of the breast cancer associated genes (BRCA1, BRCA2) is not an absolute contraindication to breast preservation, but many patients who are genetically positive and who develop DCIS seriously consider bilateral mastectomy. (Kuerer, 2010) b. Breast Conservation for PatientsShow MoreRelatedSymptoms And Treatment Of A Diabetic Patient With Cancer Patients913 Words   |  4 PagesAccording to American Cancer society individuals with stage 1 CRC have a 90% five year survival rate with only 12% five-year survival rate with individual with stage 4 CRC. Stage 4 is defined as cancer that has metastasized to distant organs that many include the liver. Current treatment for CRC involves the use of surgery, chemotherapy as well as radiation. Generally surgery is considered first line treatment for CRC in which the affected portion of the colon is removed. Since hyperglycemia inRead MoreBreast Cancer : A Complex And Heterogeneous Disease Caused By Genetic Mutations782 Words   |  4 PagesBreast cancer is a complex and heterogeneous disease caused by both genetic and non-genetic risk factors. These factors include, mutations in breast cancer-associated genes 1 and 2 (BRCA1 and BRCA2) [1]; loss or aberrant expression of the est rogen receptor (ER) [2]; human epidermal growth factor receptor (HER2) overexpression [3] ; lack of ER, progesterone receptor (PR), and epidermal growth factor receptor (EGFR) expression[4] ; high levels of receptor for the insulin-like growth factor receptorRead MoreShort Non Coding Rnas Play : The Rna And Represses The Translation Process By Controlling Gene Expression1559 Words   |  7 PagesAbstract: MicroRNAs are short non-coding RNAs play main role in human diseases; it deregulates the RNA and represses the translation process by controlling gene expression. Some deregulated miRNAs express deferentially such as mir-125b, mir-145, mir-155, and mir-21 leads for partition between cancer and normal tissues. miRNAs expression with particular cancer biopathologic features in breast, such as tumor stage, estrogen and progesterone receptor expression, vascular invasion, or proliferation indexRead MorePssc Research Paper780 Words   |  4 Pagesand Generation of Human Cardiomyocytes from iPSCs Slide 1-23 1500 words Advances in Application of iPSC-derived Cardiomyocytes for Future Medicine -Modeling Inherited cardiomyopathy with human iPSC-derived cardiomyocytes The advent of iPS cell technology and improvements in protocols for cardiomyocytes differentiation open the door to using iPSC-CMs platform for disease modeling and toxicological assays in various cardiovascular diseases. To data, one of the most successful area in research applicationRead MoreAnalysis Of Nigella Sativa And Its Effects On The Treatment Of Cancer3007 Words   |  13 Pageseffects that help explain its medicinal properties. More recently, Nigella sativa and its major active compound, thymoquinone, have become an area of interest in the treatment of cancer. As one of the leading causes of death, cancer is a dreadful disease with no known cure and treatments with high toxicity and expense. In an effort to find drugs with lower levels of toxicity, scientists have turned to naturally occurring compounds, and Nigella sativa has shown great promise. Numerous studies haveRead MoreDevelopment Of The Mammary Gland9524 Words   |  39 PagesIntroduction 1. Normal mammary gland 1.1 normal mammary gland anatomies The normal breast sits on the chest muscle, consisting mainly of adipose tissue, also known as mammary fat pad. 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A significant problem faced in treating these patients is the high rate of recurre nce associated withRead MoreHuman Kallikrein Related Peptidases ( Klks )8953 Words   |  36 PagesCancer is the second leading cause of death with 14 million new cases and 8.2 million cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies, neoplastic diseases are still a major therapeutic challenge notably because of intra- and inter-malignant tumor heterogeneity and adaptation/escape of malignant cells to/from treatment. New targeted therapies need to be developed to improve our medical arsenal and counter-act cancer progression. Human kallikrein-related peptidasesRead MoreEssay On 20 Years Of Advancement In Healthcare Science1109 Words   |  5 PagesHealthcare Science and Potential Future Developments Over the last twenty years there have been numerous important advances throughout healthcare science. These have allowed for improved diagnoses and more effective treatments lowering the prevalence of diseases. The first significant advancement discussed in this essay is The Human Genome Project (HGP), an international collaborative research program whose goal was to sequence and map all of the genes (known as the genome) contained within humans. ThisRead MoreOvarian Cancer Case Study837 Words   |  4 Pagesimmunohistochemistry in 37 samples, DICER showed a significant upregulation in high-grade serous ovarian cancer. High DICER expression was associated with absence of lymph node metastasis and a low proliferation index. DICER expression did not correlate with disease free or overall survival (16). The authors did not comment on DROSHA expression by immunohistochemistry and, thus, did not comment on the association of DROSHA with clinical factors. Additionally, only high-grade serous EOC tumor samples were examined

Friday, December 20, 2019

Technology Replacing Man - 3081 Words

Technology Replacing Man It seems that there is no escape from technology in the modern world. In 2014, all fields of expertise are rapidly being replaced by technology. From automated phones systems, to even jobs in engineering, it seems that the increase of technology is causing a high price for many individuals in the United States and around the world. The increased use of technology in businesses nationwide have caused a wide spread of elimination of many jobs. According to converge.org, â€Å"Global unemployment has now reached its highest level since the great depression of the 1930s. More than 800 million human beings are now unemployed or underemployed in the world. That figure is likely to rise sharply between now and the turns of the century as millions of new entrants enter the workforce find themselves without jobs†. This number in expected to increase dramatically in the next decade. Technology is making advancements in areas of expertise, some of which one would least expect. One of th ese areas is agriculture. Converge.com tells its readers that â€Å"New breakthroughs in the information and life sciences threaten to end much of outdoor farming by the middle decades of the coming century. The technological changes in the production of food are leading to a world without farmers, with untold consequences for the 2.4 million people who still rely on the land for their survival†. Convege.org states that â€Å"A new generation of sophisticated computer-driven robots mayShow MoreRelatedModern Technology1463 Words   |  6 Pages The debate of modern technology is one that reaches out to almost everyone in the modern era living in the United States, since it is a first world country, everybody living in the country at one point has interacted with a piece of modern technology. The evolution of technology in the last two decades has been exponentially fast, changing evolution of almost an entire generation in the way that they view things and interact with the world around them. Things such as virtual reality haveRead MoreAnalysis Of Peace And By Schumacher Writes981 Words   |  4 Pagesput them into groups and label them depending on their wealthiest. Schumacher mentions some of the false solution that the system come up with as a solution to it , for example, the system think that technology would be the solution to their problem, to save them from the disaster. Thinking technology would lead them to peace. But the people that in â€Å"their† category is only the wealthy type of people. 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Thursday, December 12, 2019

Description about Human Resource Management Practices

Question: Describe about the Human Resource Management Practices for Performance in Organisations. Answer: Literature Review The literature review is based on Human Resource Management practices for employees performance in Wesfarmers. Jiang et al., (2014) stated that Human Resource Management (HRM) refers to the policies as well as practices which are involved in carrying the human resources. This particular literature review reflects on some of the factors of HRM practices that assist in effecting the performance of the workers. The factors are recruitment and selection, compensation, performance appraisal and training (Rae, Sands Gadenne, 2015). These factors are vital for improving the performance of the employees within the organization to meet with organizational goals of Wesfarmers. Recruitment and Selection of Employees Kehoe and Wright (2013) stated that the HRM system consists of division of labour as well as specific jobs. In such a system, limited number of employee contribution exists. The employees policy specifies comprehensive rules concern progression of profession as well as compensation. Buller and McEvoy (2012) opined that recruitment and selection gives high retention to the employees. The objective of the professional recruitment strategy is to magnetize the right number of trained applicants as well as strengthen company brand within the labour marketplace. The recruitment and selection strategies should be resolute after job analysis highlights the necessary skills as well as abilities. Bratton and Gold (2012) argued that for the external recruitment of Wesfarmers, advertising media such as print, social media are to be considered. The major trends within recruitment are use of technology, development of HR responsibilities, recruitment in business and outsourcing of recruitment agen cies. Moscardo et al, (2013) opined that recruitment as well as selection fits in to add value to the HR procedures. The recruitment process is defined as the capability of the organization in order to supply new employees, remain the organization operating as well as improving the quality of human capital. The quality of process of recruitment is major driver for happiness of the managers with the services offered by the human resources. Robbins et al., (2013) stated that goal of this process is to locate the best recruitment sources, hiring process and keep the organization competitive within the marketplace. The recruitment procedure of Wesfarmers requires a strong sustain by enthusiastic recruitment software solution. Buller and McEvoy (2012) argued that many of the vendors offer various recruitment software solutions; therefore the organization requires choosing the right solution in order to meet the organizational goals. Compensations and benefits of the employees McCauley et al., (2013) stated that the researcher is searching for the factors that would affect the performance of the employee. Purce (2014) argued that one of the best ways for production of the Wesfarmers is reward package for the employees. This compensation strategy enables the economic manpower in order to maximize income in return of great effort (Bratton Gold, 2012). It also attempts to employee motivation with productivity as well as output of the organization. Intrinsic paybacks in terms of rewards as well as compensation enhance the performance of the employees to some degree. Kehoe and Wright (2013) stated that the employees are motivated when they are given monetary rewards directly for their presentation. Antonioli, Mancinelli and Mazzanti (2013) investigated that there is a positive association between compensation as well as work performance. Bratton and Gold (2012) argued that sometimes, there arises a gender differences in pay raises such as women receive higher pay than men. One of the reasons is reduced stereotyping. Antonioli, Mancinelli and Mazzanti (2013) suggested that worn has lower base pay and increase in higher pay is due to difference in amount of information available to the decision markers. Purce (2014) argued that when managers have limited information, then it tends to make stereotypical judgements. Equity theory of motivation asserts that the employee is equally treated in the organization. This theory is based on the idea that the individuals are motivated by fairness. Shields et al., (2015) suggested that higher is the individuals perception of equity, the employees are more motivated, and if it is vice versa, then they are de-motivated. Equity theory is totally based on principle that the employees should put forth a particular employment of effort that they feel contrasts fairly to the financial rew ards that they obtain. Performance appraisal of the employees Baskerville and Wood-Harper (2016) investigated that employees are developing positive attitudes when they receive high favourable outcomes. The level of financial rewards such as amount of pay that the employees receive is found to be pessimistically related to their income levels. The social rewards give a positive influence of the job performance. Buller and McEvoy (2012) opined that the management should implement a control system which should reduce cost of labour by increasing performance standards as well as maintenance of wages. Resistance in form of strikes, high rate of grievance are found to be costly for the firm in terms of productivity as well as quality. The companies are influencing the employees perception of fairness as well as pay their employees by developing a reward strategy (Antonioli, Mancinelli Mazzanti, 2013). Rensis Likerts Participative Decision Making Theory is used by the organization so that they can demonstrate the effect of the HRM on the employees pe rformance (Kehoe Wright, 2013). The employees should participate into decision making process so that they can take important decisions regarding any important situations. Wesfarmers performance appraisal considers the goals of the appraisal system such as to improve the productivity, improvement of personnel decisions such as promotion, change of job. Bratton and Gold (2012) opined that in order to develop the appraisal of system for the organization, an entrepreneur is required to consider size of their employees, goals of company, measure performance, increase in pay, communication of appraisal system as well as performance planning. Need theory complements on the statement that in which outcomes motivate people in order to contribute valuable inputs to the job as well as perform at high levels. Robbins et al., (2013) suggested that using this theory, the organizational management should motivate the employees to fulfil their needs and wants. Training of the employees According to Baskerville and Wood-Harper (2016), training can influence the performance of the employees by improving their skills, knowledge as well as development in abilities to do task. The findings of the author reveal that the training plan influences the commitment of the organization, knowledge of participants as well as organization based self-esteem. Jiang et al., (2012) indicated that the training influences the performance of the managers as well as employees. Similarly, Purce (2014) found that training program raises the employee morale as well as increases their overall performance. This program allows the employees in order to acquire greater competencies which are required in order to perform jobs effectively as well as accurately as per the organizational requirements. Antonioli, Mancinelli and Mazzanti (2013) opined that training is given four basic grounds for the new candidates such as it familiarizes to the mission, vision, rules as well as regulations of the company. The existing employees are trained in order to enhance the knowledge. It also takes place when there is requirement for any amendments; it comes up with the changes. Finally, when career growth becomes important for the organization, then training should be given so that the employees prepare to share their responsibilities of higher level job. Shields et al., (2015) argued that due to importance of training program, a trainer can encounter resistance from both employees as well as managers. In order to successfully develop training as well as development program of the organization, the management should provide a job description upon which the activities of employee training is built. Training is mainly provided to meet with basic competencies of the job, and it is to be done by the supervisor. Research Methodology Research Philosophy While conducting a research, the research philosophy deals with the nature as well as development of knowledge. Collection of secondary data and engaged into the data analysis in order to reply to the research questions helps in creation of new knowledge (Baskerville Wood-Harper, 2016). In order to address research philosophy in the study involves in awareness as well as formulating of assumptions (O'Leary, 2013). There are three philosophies that are used such as positivism, realism and interpretivism. For this particular study, interpretivism is to be chosen as a research philosophy as this work depends on optional information gathering and this strategy is the best to check the experiences and the background of Wesfarmers. The secondary information ought to be gathered effectively with utilizing this theory (Buller McEvoy, 2012). Aside from this, the mistakes in the information investigation are likewise moderated effectively. Research Approach There are two types of research approach for this study such as deductive and inductive approach. In this particular research study, inductive approach is used. It starts with the research questions, aims as well as objectives that are required to achieve during the research process. It is considered as perfect for this study as it relates the examination point with research questions and it helps the examiner to do useful investigation with the gathered information. Research Design Ritchie et al., (2013) stated that this is the design which structure the scientific work for the study. It also gives direction of the research. The method which is chosen to do the data analysis will affect the results as well as concludes on the findings of the research. Most of the researchers are interested in getting the result through reliable observations which help them to understand the research topic as well as research questions. It is the course of action of the conditions to gather the information investigation of the information in such a methodology such, to the point that it expects to consolidate centrality to the motivation behind examination with the theoretical framework in the process (O'Leary, 2013). Mainly, there are three types of research design processes such as exploratory, explanatory as well as descriptive. In this particular study, descriptive research design is perfect as it helps to conclude the findings of the study. Utilization of this examination outline empowers to pick up data on the qualities of the specific individual to do the basic business work (Baskerville Wood-Harper, 2016). Through use of this specific examination plan, distinctive task variables are cleared and justifiable. Data collection procedure and methods Data collection procedure Mainly, there are two kinds of data collection procedures like quantitative and in addition qualitative methodology. The quantitative methodology includes the gathering of information that is putting the examination in formal too rigid technique. The qualitative methodology depends on the techniques for subjective assessment of suppositions and additionally states of mind (Ritchie et al., 2013). Utilizing this approach, the investigator can do inside and out examination on the exploration point and do analysis on the gathering data from publicly available sources like case studies of Wesfarmers, websites of the company and many others. In this specific exploration concentrate on, the information is dissected utilizing the subjective information accumulation methodology to comprehend the HRM practices for employees performance in Wesfarmers. Data collection method In this particular study, secondary data collection method is used. The data are collected by means in order to overcome with difficulties to gain access to the managers with a sample group those have approaches pertaining to the research questions. The data for the secondary data are collected from the publicly available sources like case studies of Wesfarmers, websites of the company, press articles, financial reports of the company, journals, published interviews and news releases. Ritchie et al., (2013) identified some of the benefits of the secondary data collection method are much of the data are available within public domain. Due to selection of public cases on the company, the cases ensure the validity of the data as well as findings. As the data are open to the public scrutiny, therefore they are of high standard (O'Leary, 2013). It is the skill of the experts that the annual reports of the company are offered of high quality which gives high-quality HRM strategies of the c ompany. References Antonioli, D., Mancinelli, S., Mazzanti, M. (2013). Is environmental innovation embedded within high-performance organisational changes? The role of human resource management and complementarity in green business strategies.Research Policy,42(4), 975-988. Baskerville, R. L., Wood-Harper, A. T. (2016). A critical perspective on action research as a method for information systems research. InEnacting Research Methods in Information Systems: Volume 2(pp. 169-190). Springer International Publishing. Bratton, J., Gold, J. (2012).Human resource management: theory and practice. Palgrave Macmillan. Buller, P. F., McEvoy, G. M. (2012). Strategy, human resource management and performance: Sharpening line of sight.Human resource management review,22(1), 43-56. Jiang, K., Lepak, D. P., Han, K., Hong, Y., Kim, A., Winkler, A. L. (2012). Clarifying the construct of human resource systems: Relating human resource management to employee performance.Human Resource Management Review,22(2), 73-85. Jiang, K., Lepak, D. P., Hu, J., Baer, J. C. (2012). How does human resource management influence organizational outcomes? A meta-analytic investigation of mediating mechanisms.Academy of management Journal,55(6), 1264-1294. Kehoe, R. R., Wright, P. M. (2013). The impact of high-performance human resource practices on employees attitudes and behaviors.Journal of management,39(2), 366-391. McCauley, C. D., Derue, D. S., Yost, P. R., Taylor, S. (2013).Experience-driven leader development: Models, tools, best practices, and advice for on-the-job development. John Wiley Sons. Moscardo, G., Lamberton, G., Wells, G., Fallon, W., Lawn, P., Rowe, A., ... Renouf, M. (2013).Sustainability in Australian business: Principles and practice. Wiley-Blackwell. O'Leary, Z. (2013).The essential guide to doing your research project. Sage. Purce, J. (2014). The impact of corporate strategy on human resource management.New Perspectives on Human Resource Management (Routledge Revivals),67. Rae, K., Sands, J., Gadenne, D. L. (2015). Associations between organisations motivated workforce and environmental performance.Journal of Accounting Organizational Change,11(3), 384-405. Ritchie, J., Lewis, J., Nicholls, C. M., Ormston, R. (Eds.). (2013).Qualitative research practice: A guide for social science students and researchers. Sage. Robbins, S., De Cenzo, D., Coulter, M., Woods, M. (2013).Management: the essentials. Pearson Higher Education AU. Shields, J., Brown, M., Kaine, S., Dolle-Samuel, C., North-Samardzic, A., McLean, P., ... Plimmer, G. (2015).Managing Employee Performance Reward: Concepts, Practices, Strategies. Cambridge University Press.

Wednesday, December 4, 2019

An Analysis on a Mcdonalds Advertisement Essay Example For Students

An Analysis on a Mcdonalds Advertisement Essay Analysis on the McDonalds advertisement We have recently been studying the McDonalds advertisement where they have stated that they are helping Aussie families and the future sports stars of tomorrow. They tell us that they are hand in hand with Australian families, but they only say that because they want more families to go to their local McDonalds store. But are they really helping the sports stars. Yes of course they are but they aren’t really helping out as much as they say. Yeah they do sponsor teams but really I am sure that they only do it for the advertisement on the jerseys. Did you notice that after most sports game most coaches have a McDonalds voucher to give out. That is another way how McDonalds thinks that they are helping young sports stars; by giving these vouchers out they are encouraging the young participants but they are also showing them the way to unhealthy food. This makes them work harder just so they can get McDonalds. They use informal and colloquial language to persuade people of various communities to go and buy this unhealthy food so they can support their sons/daughters/relatives or really anyone that is participating in sport, so that they can support their dreams and their goals for their future goals. Also because they want to make sure that these kids can have a proper life, not one that is totally messed up because no one was there to help them reach their dreams and goals. They believe that they are giving something back to the community by helping the young stars of tomorrow. They figure that by helping people think that they are doing the right thing but really they are leading the children down the path of unhealthy food which may end up leading to being obese or even having diabetes which isn’t a good life for anyone. I am sure that you wouldn’t want to be a young adult with diabetes, obese or have a serious heart condition. I am sure that the answer to that is no. I think that the McDonalds advertisement team should really think about what they are leading people to before they publish any real advertisement in the future.